名古屋大学
大学院生命農学研究科・農学部
食品機能化学研究室
Laboratory of Food and Biodynamics
研究業績
2023年
Sasayama Y, Mamiya T, Qi J, Shibata T, Uchida K, Nabeshima T, Ojika M. (2023)
Bioorg. Med. Chem. 78, 117144.
Hayasaka R, Tabata S, Hasebe M, Ikeda S, Hikita T, Oneyama C, Yoshitake J, Onoshima D, Takahashi K, Shibata T, Uchida K, Baba Y, Soga T, Tomita M, Hirayama A. (2023)
Front. Mol. Biosci. 9, 1049402.
Okuda K, Nakahara K, Ito A, Iijima Y, Nomura R, Kumar A, Fujikawa K, Adachi K, Shimada Y, Fujio S, Yamamoto R, Takasugi N, Onuma K, Osaki M, Okada F, Ukegawa T, Takeuchi Y, Yasui N, Yamashita A, Marusawa H, Matsushita Y, Katagiri T, Shibata T, Uchida K, Niu SY, Lang NB, Nakamura T, Zhang KYJ, Lipton SA, Uehara T. (2023)
Nat. Commun. 14, 621.
Nakashima F, Giménez-Bastida JA, Luis PB, Presley SH, Boer RE, Chiusa M, Shibata T, Sulikowski GA, Pozzi A, Schneider C. (2023) The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis.
J. Biol. Chem. 299, 103050.
2022年
Nishiyama K, Nishimura A, Shimoda K, Tanaka T, Kato Y, Shibata T, Tanaka H, Kurose H, Azuma YT, Ihara H, Kumagai Y, Akaike T, Eaton P, Uchida K, Nishida M. (2022)
Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression.
Sci. Signal. 15, eabj0644
Itakura M, Yamaguchi K, Kitazawa R, Lim SY, Anan Y, Yoshitake J, Shibata T, Negishi L, Sugawa H, Nagai R, Uchida K. (2022)
Histone functions as a cell-surface receptor for AGEs.
Nat. Commun. 13, 2974
Hattori H, Moriyama A, Ohno T, Shibata T, Iwahashi H, Mitsunaga T. (2022)
Molecular networking-based lipid profiling and multi-omics approaches reveal new contributions of functional vanilloids to gut microbiota and lipometabolism changes.
Food Chem. Mol. Sci. 5, 100123
Yoshitake J, Azami M, Sei H, Onoshima D, Takahashi K, Hirayama A, Uchida K, Baba Y, Shibata T. (2022)
Rapid Isolation of Extracellular Vesicles Using a Hydrophilic Porous Silica Gel-Based Size-Exclusion Chromatography Column.
Anal. Chem. 94, 13676-13681.
2021年
Yoshioka K, Yamashita H, Shimizu K, Shimomura S, Shibata T, Miyazaki JI, Honda H. (2021)
Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution.
Biochem. Biophys. Res. Commun. 550, 177-183
Hasegawa K, Kuwata K, Yoshitake J, Shimomura S, Uchida K, Shibata T. (2021)
Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor.
FEBS J. 288, 1906-1917
Hattori H, Mori T, Shibata T, Kita M, Mitsunaga T. (2021)
6-Paradol acts as a potential anti-obesity vanilloid from Grains of Paradise.
Mol. Nutr. Food Res. 65, e2100185
Ariyoshi S, Imazu Y, Ohguri R, Katsuta R, Yajima A, Shibata T, Ojika M. (2021)
Identification of biosynthetic intermediates for the mating hormone α2 of the plant pathogen Phytophthora.
Biosci. Biotechnol. Biochem. 85, 1802-1808
Oshimo M, Nakashima F, Kai K, Matsui H, Shibata T, Akagawa M. (2021)
Sodium sulfite causes gastric mucosal cell death by inducing oxidative stress.
Free. Radic. Res. 55, 731-743
Yamaguchi K, Itakura M, Kitazawa R, Lim SY, Nagata K, Shibata T, Akagawa M, Uchida K. (2021)
Oxidative deamination of lysine residues by polyphenols generates an equilibrium of aldehyde and 2-piperidinol products.
J. Biol. Chem. 297, 101035
Katayoshi T, Kusano Y, Shibata T, Uchida K, Tsuji-Naito K. (2021)
Low-molecular-weight whey proteins promote collagen production in dermal fibroblasts via the TGF-β receptor/Smad pathway.
Biosci Biotechnol Biochem 85, 2232-2240
Tanaka H, Hosoi Y, Ishikawa K, Yoshitake J, Shibata T, Uchida K, Hashizume H, Mizuno M, Okazaki Y, Toyokuni S, Nakamura K, Kajiyama H, Kikkawa F, Hori M. (2021)
Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified.
Sci. Rep. 11, 18488
Kinoshita R, Kozaki I, Shimizu K, Shibata T, Ochiai A, Honda H. (2021)
Agonist/antagonist activity of oxytocin variants obtained from free cyclic peptide libraries generated via amino acid substitution.
ACS Omega 6, 31244-31252
2020年
Nakashima F, Shibata T, Uchida K. (2020)
A unique mechanism for thiolation of serum albumins by disulfide molecules. (Review)
J. Biochem. 167, 165-171.
Nakagawa Y, Sawaki Y, Miyanishi W, Shimomura S, Shibata T, Ojika M. (2020)
Relationship among structure, cytotoxicity, and Michael acceptor reactivity of quinocidin.
Bioorg. Med. Chem. 28, 115308.
Sasatsuki H, Nakazaki A, Uchida K, Shibata T. (2020)
Quantitative analysis of oxidized vitamin B1 metabolites generated by hypochlorous acid.
Free Radic. Biol. Med. 152, 197-206.
Chikazawa M, Yoshitake J, Lim SY, Iwata S, Negishi L, Shibata T, Uchida K. (2020)
Glycolaldehyde is an endogenous source of lysine N-pyrrolation.
J. Biol. Chem. 2020 295, 7697-7709.
Zhang M, Sunaba T, Sun Y, Shibata T, Sasaki K, Isoda H, Kigoshi H, Kita M. (2020)
J. Antibiot. 73, 589-592.
Hirukawa M, Zhang M, Echenique-Diaz LM, Mizota K, Ohdachi SD, Begué-Quiala G, Delgado-Labañino JL, Gámez-Díez J, Alvarez-Lemus J, Galano Machado L, Suárez Núñez, M, Shibata T, Kigoshi H, Kita M. (2020)
Isolation and structure-activity relationship studies of jacaranones: anti-inflammatory quinoids from the Cuban endemic plant Jacaranda arborea (Bignoniaceae).
Tetrahedron Lett. 61, 152005.
Luong NC, Abiko Y, Shibata T, Uchida K, Warabi E, Suzuki M, Noguchi T, Matsuzawa A, Kumagai Y. (2020)
J. Toxicol. Sci. 45, 349-363.
Takamiya R, Takahashi M, Maeno T, Saito A, Kato M, Shibata T, Uchida K, Ariki S, Nakano M. (2020)
Acrolein in cigarette smoke attenuates the innate immune responses mediated by surfactant protein D.
Biochim. Biophys. Acta Gen. Subj. 1864, 129699.
Kamata S, Oyama T, Saito K, Honda A, Yamamoto Y, Suda K, Ishikawa R, Itoh T, Watanabe Y, Shibata T, Uchida K, Suematsu M, Ishii I.(2020)
PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
iScience 23, 101727.
中島史恵、柴田貴広、内田浩二 (2020) “システイン残基におけるユニークな自然修飾”
実験医学増刊 「食と健康を結ぶメディカルサイエンス」 (内田浩二 編集) 羊土社 第１章 p52-58.
柴田貴広(2020) “細胞膜受容体の活性制御を介した食品成分の機能性”
実験医学増刊 「食と健康を結ぶメディカルサイエンス」 (内田浩二 編集) 羊土社 第３章 p162-166.
2019年
Ihara H, Kakihana Y, Yamakage A, Kai K, Shibata T, Nishida M, Yamada KI, Uchida K. (2019)
2-Oxo-histidine-containing dipeptides are functional oxidation products.
J. Biol. Chem. 294, 1279-1289.
Yoshitake J, Shibata T, Shimayama C, Uchida K. (2019)
2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct.
Redox Biol. 23, 101115.
Shibata T, Uchida K. (2019)
Protein adductomics: A comprehensive analysis of protein modifications by electrophiles. (Review)
Free Radic. Biol. Med. 144, 218-222.
Apolipoprotein E binds to and reduces serum levels of DNA-mimicking, pyrrolated proteins.
J. Biol. Chem. 294, 11035-11045.
Guerby P, Swiader A, Tasta O, Pont F, Rodriguez F, Parant O, Vayssière C, Shibata T, Uchida K, Salvayre R, Negre-Salvayre A. (2019)
Free Radic. Biol. Med. 141, 416-425.
Suzuki T, Muramatsu A, Saito R, Iso T, Shibata T, Kuwata K, Kawaguchi SI, Iwawaki T, Adachi S, Suda H, Morita M, Uchida K, Baird L, Yamamoto M. (2019)
Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1.
Cell Rep. 28, 746-758. e4.
Martin-Rubio AS, Sopelana P, Nakashima F, Shibata T, Uchida K, Guillén MD. (2019)
A Dual Perspective of the Action of Lysine on Soybean Oil Oxidation Process Obtained by Combining 1H NMR and LC-MS: Antioxidant Effect and Generation of Lysine-Aldehyde Adducts.
Antioxidants 8, 326
Kusano Y, Tsujihara N, Masui H, Shibata T, Uchida K, Takeuchi W. (2019)
Diosgenin Supplementation Prevents Lipid Accumulation and Induces Skeletal Muscle-Fiber Hypertrophy in Rats.
J. Nutr. Sci. Vitaminol. 65, 421-429.
2018年
Nakashima F, Shibata T, Kamiya K, Yoshitake J, Kikuchi R, Matsushita T, Ishii I, Giménez-Bastida JA, Schneider C, Uchida K. (2018)
Structural and functional insights into S-thiolation of human serum albumins.
Sci. Rep. 8, 932.
Uchida K, Shibata T, Toyokuni S, Daniel B, Zarkovic K, Zarkovic N, Sasson S. (2018)
Development of a novel monoclonal antibody against 4-hydroxy-2E,6Z-dodecadienal (4-HDDE)-protein adducts: Immunochemical application in quantitative and qualitative analyses of lipid peroxidation in vitro and ex vivo.
Free Radic. Biol. Med. 124, 12-20.
中島史恵、柴田貴広、内田浩二 (2018) “脂質異常症に関連したタンパク質のS-チオール化”
実験医学増刊 「レドックス疾患学」 (赤池孝章、本橋ほづみ、内田浩二、末松誠 編集) 羊土社 第3章 264-270.
柴田貴広、内田浩二 (2018) “プロスタグランジンD2代謝物に関する最近の話題”
生化学 90, 711-714.
2017年
Kuan, Y.C., Hashidume, T., Shibata, T., Uchida, K., Shimizu, M., Inoue, J., Sato, R. (2017)
Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein.
J. Biol. Chem. 292, 3016-3028.
Dong, J., Shichiri, M., Chung, C.I., Shibata, T., Uchida, K., Hagihara, Y., Yoshida, Y., Ueda, H. (2017)
An open sandwich immunoassay for detection of 13(R,S)-hydroxy-9(E), 11(E)-octadecadienoic acid.
Analyst. 142, 787-793.
Shibata, T., Shimizu, K., Hirano, K., Nakashima, F., Kikuchi, R., Matsushita, T., Uchida, K. (2017)
Adductome-based identification of biomarkers for lipid peroxidation.
J. Biol. Chem. 292, 8223-8235.
Giménez-Bastida, J.A., Shibata, T., Uchida, K., Schneider, C. (2017)
Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes.
FASEB J. 31, 1867-1878
Luis, P.B., Gordon, O.N., Nakashima, F., Joseph, A.I., Shibata, T., Uchida, K., Schneider, C. (2017)
Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes.
Biochem. Pharmacol. 132, 143-149
Nakazaki, A., Hashimoto, K., Ikeda, A., Shibata, T., Nishikawa, T. (2017)
De Novo Synthesis of Possible Candidates for the Inagami-Tamura Endogenous Digitalis-like Factor.
J. Org. Chem. 82, 9097-9111.
Furuhashi, M., Hatasa, Y., Kawamura, S., Shibata, T., Akagawa, M., Uchida, K. (2017)
Identification of Polyphenol-Specific Innate Epitopes That Originated from a Resveratrol Analogue.
Biochemistry. 56, 4701-4712.
Takamiya, R., Uchida, K., Shibata, T., Maeno, T., Kato, M., Yamaguchi, Y., Ariki, S., Hasegawa, Y., Saito, A., Miwa, S., Takahashi, H., Akaike, T., Kuroki, Y., Takahashi, M. (2017)
Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke.
Sci Rep. 7, 8304.
Enoki, M., Shinto, S., Matsuoka, Y., Otsuka, A., Kaidzu, S., Tanito, M., Shibata, T., Uchida, K., Ohira, A., Yamato, M., Yamada, K.I. (2017)
Lipid radicals cause light-induced retinal degeneration.
Chem. Commun. (Camb). 53, 10922-10925.
2016年
Hatasa, Y., Chikazawa, M., Furuhashi, M., Nakashima, F., Shibata, T., Kondo, T., Akagawa, M., Hamagami, H., Tanaka, H., Tachibana, H., and Uchida, K. (2016)
Oxidative Deamination of Serum Albumins by (-)-Epigallocatechin-3-O-Gallate: A Potential Mechanism for the Formation of Innate Antigens by Antioxidants.
PLoS ONE. 11, e0153002.
Akagawa, M., Minematsu, K., Shibata, T., Kondo, T., Ishii, T., and Uchida, K. (2016)
Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein.
Sci. Rep. 6, 26723.
Citron, B. A., Ameenuddin, S., Uchida, K., Suo, W. Z., SantaCruz, K., and Festoff, B. W. (2016)
Membrane lipid peroxidation in neurodegeneration: Role of thrombin and proteinase-activated receptor-1.
Brain Res. 1643, 10-17.
Nokin, M. J., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoi, A., Costanza, B., Smargiasso, N., Baiwir, D., De Tullio, P., Bianchi, E., Thiry, M., Uchida, K., Spiegel, D. A., Hutton, C. A., De Pauw, E., Delvenne, P., Belpomme, D., Castronovo, D., and Bellahcène, A. (2016)
Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis.
eLife 5, e19375.
Chikazawa, M., Shibata, T., Hatasa, Y., Hirose, S., Otaki, N., Nakashima, F., Ito, M., Machida, S., Maruyama, S., Uchida, K. (2016)
Identification of C1q as a Binding Protein for Advanced Glycation End Products.
Biochemistry 55, 435-446.
Shibata, T., Takahashi, K., Matsubara, Y., Inuzuka, E., Nakashima, F., Takahashi, N., Kozai, D., Mori, Y., Uchida, K. (2016)
Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel.
Sci. Rep. 6, 21261.
中島史恵、柴田貴広、内田浩二 (2016) “ケルセチンおよびケルセチン配糖体によるToll様受容体シグナリング抑制”
ポリフェノール学会誌.
内田浩二 (2016) “レドックスバイオロジーから見た食品と生体防御反応”
実験医学 「予防医学の扉を開く食品に秘められたサイエンス」 34, 2370-2373.
内田浩二、柴田貴広 (2016) “生体と酸化ストレス”
ヒトの基礎生化学 (川上浩、太田正人 編著) アイ・ケイコーポレーション, 14章 197-202.
2015年
Kumagai, T., Usami, H., Matsukawa, N., Nakashima, F., Chikazawa, M., Shibata, T., Noguchi, N., and Uchida, K. (2015)
Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile.
Redox Biol. 4, 74-86.
Larroque-Cardoso, P., Camaré, C., Nadal-WollboldF., Grazide, M. H., Pucelle, M., Garoby-Salom, S., Bogdanowicz, P., Josse, G., Schmitt, A. M., Uchida, K., Zarkovic, K., Salvayre, R., and Nègre-Salvayre, A. (2015)
Elastin modification by 4-hydroxynonenal in hairless mice exposed to UV-A. Role in photoaging and actinic elastosis.
J. Invest. Dermatol. 135, 1873-1881.
Koutakis, P., Myers, S. A., Cluff, K., Ha, D. M., Haynatzki, G., McComb, R. D., Uchida, K., Miserlis, D., Papoutsi, E., Johanning, J. M., Casale, G. P., and Pipinos, I. I. (2015)
Abnormal myofiber morphology and limb dysfunction in claudication.
J. Surg. Res. 196, 172-179.
Arcaro, A., Daga, M., Paolo Cetrangolo, G., Ciamporcero, E., Lepore, A., Pizzimenti, A., Petrella, C., Graf, M., Uchida, K., Mamone, G., Ferranti, P., Julian Ames, R., Palumbo, G., BarreraG., Gentile, F. (2015)
Generation of adducts of 4-hydroxy-2-nonenal with heat shock 60kDa protein 1 in human promyelocytic HL-60 and monocytic THP-1 cell lines.
Oxid Med. Cell. Longev. 2015, Article ID 296146.
Yin, H., Niki, E., and Uchida, K. (2015)
Special issue on "Recent progress in lipid peroxidation based on novel approaches".
Free Radic. Res. 49, 813-815
Uchida, K. (2015)
Aldehyde adducts generated during lipid peroxidation modification of proteins.
Free Radic. Res. 49, 896-904.
熊谷嘉人、内田浩二 (2015) “RSSによる環境中親電子物質の解毒代謝”
細胞工学「活性イオウ分子種の生理機能に迫る チオールバイオロジーの新たなステージ」358-363.
内田浩二 (2015) “酸化的な生体分子修飾と自己抗体産生”
別冊医学のあゆみ「レドックスUPDATE：ストレス制御の臨床医学・健康科学」（平家俊男、淀井淳司 監修）医歯薬出版、26-30.
近澤未歩、内田浩二 (2015) ミニレビュー“内因性抗原としての陰性荷電分子の生成と制御”
生化学 87, 776-778.
柴田貴広、内田浩二 (2015) “アダクトーム解析法を用いた新しい疾患バイオマーカーの探索”
バイオサイエンスとバイオインダストリー、74, 26-29.